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Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals.
Nat. Metab. 6, 678-686 (2024)
Non-invasive glucose monitoring (NIGM) represents an attractive alternative to finger pricking for blood glucose assessment and management of diabetes. Nevertheless, current NIGM techniques do not measure glucose concentrations in blood but rely on indirect bulk measurement of glucose in interstitial fluid, where glucose is diluted and glucose dynamics are different from those in the blood, which impairs NIGM accuracy. Here we introduce a new biosensor, termed depth-gated mid-infrared optoacoustic sensor (DIROS), which allows, for the first time, non-invasive glucose detection in blood-rich volumes in the skin. DIROS minimizes interference caused by the stratum corneum and other superficial skin layers by time-gating mid-infrared optoacoustic signals to enable depth-selective localization of glucose readings in skin. In measurements on the ears of (female) mice, DIROS displays improved accuracy over bulk-tissue glucose measurements. Our work demonstrates how signal localization can improve NIGM accuracy and positions DIROS as a holistic approach, with high translational potential, that addresses a key limitation of current NIGM methods.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
2522-5812
e-ISSN
2522-5812
Zeitschrift
Nature metabolism
Quellenangaben
Band: 6,
Heft: 4,
Seiten: 678-686
Verlag
Springer
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Biological and Medical Imaging (IBMI)
Institute of Computational Biology (ICB)
Institute of Computational Biology (ICB)
Förderungen
DZHK (German Centre for Cardiovascular Research)
Deutsche Forschungsgemeinschaft (DFG)
European Research Council (ERC)
Horizon Europe research and innovation programme
European Union
Deutsche Forschungsgemeinschaft (German Research Foundation)
Deutsche Forschungsgemeinschaft (DFG)
European Research Council (ERC)
Horizon Europe research and innovation programme
European Union
Deutsche Forschungsgemeinschaft (German Research Foundation)