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Minimal SC-ß-Cell properties for transplantation in diabetic patients.
In: Pluripotent Stem Cell Therapy for Diabetes. 2024. 529-545 (Pluripotent Stem Cell Therapy for Diabetes, First Edition)
Pancreatic ß cells within the islets of Langerhans are the body’s main source for insulin. ß cells maintain glucose homeostasis through the tight control of insulin secretion and cessation in response to changes in blood glucose levels. The loss of ß cells or ß-cell dysfunction leads to the development of diabetes. Diabetes is a prevalent metabolic disease that affects populations worldwide. Considerable efforts are underway to develop therapies and treatments to combat diabetes. Transplantation of stem cell-derived ß cells (SC-ß cells) is a promising cell replacement therapy for curing diabetes. Significant advancements have been made toward generating functional SC-ß cells in laboratories. Here, we describe the essential properties of human ß cells that need to be reproduced in stem cell-derived insulin-producing cells to ensure functionality and safety.
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Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter
Ca Signaling 2+ ; Clinical Trial ; Diabetes ; First-phase And Second-phase Insulin Secretion ; Insulin Secretion ; Islets Of Langerhans ; Metabolism ; Sc-ß Cells ; ß Cells ; ß-cell Maturation
ISSN (print) / ISBN
[9783031419430, 9783031419423]
Bandtitel
Pluripotent Stem Cell Therapy for Diabetes
Quellenangaben
Seiten: 529-545
Institut(e)
Institute for Diabetes und Organoid Technology (IDOT)