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Beckers, J. ; Valera, G.* ; Raess, M.*

INFRAFRONTIER – the European Research Infrastructure for In Vivo and In Vitro Diseases Modelling.

In: (RExPO25, 24-26 September 2025, Barcelona, Spain). 2025.
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Page 1RExPO25 — From Literature to Knowledge Graphs to Drug RepurposingRExPO25BARCELONA, SPAIN , 24-26 SEPTEMBER 2025INFRAFRONTIER – the European ResearchInfrastructure for In Vivo and In Vitro DiseasesModellingJohannes Beckers , Gema Valera Vázquez , Michael RaessINFRAFRONTIER ERICHelmholtz Zentrum München GmbHTechnical University MunichGerman Center for Diabetes Research (DZD)AbstractINFRAFRONTIER, is a non-profit organisation dedicated to advancing the understanding and treatment ofhuman diseases through state-of-the-art in vivo and in vitro models. Comprised of a network of over 20cutting-edge biomedical research institutes across Europe and beyond, INFRAFRONTIER enables thegeneration, phenotyping, archiving, and distribution of advanced mouse and rat models. It also supports thedevelopment and validation of in vitro model systems and the establishment of associated FAIR dataresources. Moreover, INFRAFRONTIER offers the generation of germ-free animals for axenic andgnotobiotic experimentation in biomedical research, together with access to advanced Preclinical BioSafetyLevel 3 services for in vivo testing of infectious disease therapeutics.Operating one of the world’s largest mouse repositories, INFRAFRONTIER empowers scientists inacademia and industry to advance research into human health and disease. Committed to excellence, itapplies rigorous and standardised protocols that prioritise animal welfare and supports the refinement,reduction, and replacement (3R) of animal models. Through close collaboration with other Europeanresearch infrastructures, INFRAFRONTIER promotes the global exchange of FAIR research data andprovides remote research services. These partnerships help to build a better connected European researchcommunity that can respond swiftly, effectively, and cooperatively to major health challenges.INFRAFRONTIER leads the INFRAPLUS and PRIM-TECH3R projects, which will strengthen its capacity forhuman disease modelling, reduce animal use, and develop advanced in vitro models. Building on itsexpertise in model generation, characterisation, validation, collaborative research, and data integration,INFRAFRONTIER is well positioned for a significant contribution to drug repurposing in Europe and beyond.
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Publikationstyp Artikel: Konferenzbeitrag
Schlagwörter Research Infrastructure, disease models, in vivo models, in vitro models, animal welfare, drug repurposing
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
Konferenztitel RExPO25
Konferzenzdatum 24-26 September 2025
Konferenzort Barcelona, Spain
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500600-004
DOI 10.58647/rexpo.25000129.v1
Erfassungsdatum 2025-10-17
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