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Roth, D. ; Zampa, B. ; Augustin, R. ; Payandehjoo, D. ; Porcella, G. ; Sahin, A.T. ; van der Does, A.M.* ; Nawroth, J.

Release, transfer, fold: Using a silicone adhesive for on-demand 3D tissue engineering.

ACS Biomater. Sci. Eng., DOI: 10.1021/acsbiomaterials.5c01130 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Conventional cell culture substrates are flat and rigid, locking cells in a permanent and unphysiological geometry. Advanced tissue culture models that emulate the dynamic and 3D environments of organs remain challenging to generate. Here, we establish flexible silicone adhesive films as versatile substrates that enable the on-demand release, transfer, and folding of cultured 2D tissues into 3D geometries. We rolled primary epithelial cultures into tubes, assembled cuboidal structures, and transferred primary endothelial cultures between culture environments for coculturing. Our approach provides an easy-to-implement platform for dynamic geometrical designs in tissue engineering.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 3d ; Adhesives ; Flexible Tissue Engineering ; Foldable ; Low-cost Technology ; Primary Cell Cultures
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2373-9878
e-ISSN 2373-9878
Zeitschrift ACS Biomaterials Science and Engineering
Verlag American Chemical Society (ACS)
Verlagsort 1155 16th St, Nw, Washington, Dc 20036 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30203 - Molecular Targets and Therapies
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Pioneer Campus
Enabling and Novel Technologies
PSP-Element(e) G-510009-001
G-505500-001
Förderungen
European Research Council (ERC)
European Research Council (ERC) under the European Union's Horizon Europe research and innovation programme
HORIZON EUROPE European Research Council
DOI 10.1021/acsbiomaterials.5c01130
WOS ID 001591530600001
PubMed ID 41075261
Erfassungsdatum 2025-10-14
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