PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Gillet, J.P.* ; Gerard, L.* ; Vieira, W.* ; Fourrez, M.* ; Gaudray, F.* ; Rathkolb, B. ; Rozman, J. ; Klein-Rodewald, T. ; Becker, L. ; Aguilar-Pimentel, J.A. ; Horsch, M. ; Spielmann, N. ; Prehn, C. ; Bihin, B.* ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Southon, E.* ; Tessarollo, L.* ; Xia, D.* ; Gottesman, M.M.*

Abcb5-deficient mice show a subtle, pleiotropic phenotype indicating a role for this transporter in intermediary metabolism.

iScience 28:113617 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
ABCB5 is a member of the ATP-binding cassette transporter superfamily that is expressed as a full transporter (ABCB5FL) and half transporter (ABCB5β). The ABCB5FL transporter mediates low-level multidrug resistance in cancer and is normally expressed in the prostate and testis, while ABCB5β has been found to be a marker of melanoma and limbal stem cells and is expressed in pigmented cells. To explore ABCB5’s role in normal physiology, we generated Abcb5-deficient C57BL/6J mice by the deletion of Abcb5 exon 2, knocking out both forms of ABCB5, which were completely phenotyped. The mice were fertile and demonstrated altered bioenergetics and fat metabolism, along with alterations in their blood composition, including anisocytosis and decreased white blood cells and platelet counts. This study uncovers further avenues of investigation into the role of Abcb5 in intermediary metabolism, particularly in relation to atherogenesis.
Impact Factor
Scopus SNIP
Altmetric
4.100
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cancer ; Cell Biology ; Physiology; Binding Cassette Transporter; Atp-binding; Gene-expression; P-glycoprotein; Mouse; Cholesterol; Abcb5; Cells; Echocardiography; Resistance
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2589-0042
e-ISSN 2589-0042
Zeitschrift iScience
Quellenangaben Band: 28, Heft: 10, Seiten: , Artikelnummer: 113617 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
CF Metabolomics & Proteomics (CF-MPC)
POF Topic(s) 30201 - Metabolic Health
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Genetics and Epidemiology
Enabling and Novel Technologies
PSP-Element(e) G-500692-001
G-500600-001
A-630710-001
G-500600-004
Förderungen NIH
German Center for Diabetes Research (DZD)
German Federal Ministry of Education and Research
DOI 10.1016/j.isci.2025.113617
WOS ID 001596199200005
Scopus ID 105018026580
PubMed ID 41142997
Erfassungsdatum 2025-10-13
[➜Korrektur melden]