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Feindor, M.* ; Hewings, S.* ; Goodman, J.* ; Young, H.* ; Galan, C.* ; Huber, P.* ; Buters, J.T.M. ; Bergmann, C.* ; Cuevas, M.* ; Jensen-Jarolim, E.* ; Oteros, J.* ; Sailer, M.M.* ; Joest, M.* ; Werminghaus, P.* ; Graessel, A.* ; Hernandez, D.* ; Skinner, M.* ; Kramer, M.F.*

Broad-spectrum grass pollen immunotherapy: Revisiting the role of species diversity in allergy treatment.

Curr. Treat. Options Allerg. 13:4 (2026)
Verlagsversion DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Purpose of Review: This review examines whether allergen immunotherapy (AIT) for grass pollen allergy should expand beyond the recent trend towards a mono-species approach based on Phleum pratense. It explores whether multi-species formulations better reflect natural exposure and could improve clinical outcomes. Recent Findings: Research from aerobiology and immunology shows that grass pollen exposure involves diverse species with distinct flowering periods, influenced by climate and geography. Molecular analyses reveal species-specific allergen profiles, including unique peptides and variations in major allergens such as Group 1 and 5. Patient data confirm symptom variability across the season. In-vitro studies have observed limits to the cross-reactivity of T-cell epitopes, and comparative clinical studies suggest benefits for multi-species treatment options. Summary: Evidence indicates that mono-species extracts alone do not represent the full allergenic spectrum of grass pollen. Broad-spectrum AIT formulations incorporating multiple grass species provide a more comprehensive repertoire of allergens and epitopes, potentially enhancing immunogenicity and therapeutic benefit. This supports the hypothesis that diversity does not equate to dilution in broad-spectrum formulations. The approach aligns with patient symptom patterns and may improve efficacy and asthma prevention. Future research could further refine species selection and leverage molecular diversity to optimize treatment strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Aerobiology ; Allergen Immunotherapy ; Allergic Rhinitis ; Climate Change ; Grass Pollen Allergy; Cross-reactivity; Poaceae; Aeroallergens; Season
ISSN (print) / ISBN 2196-3053
e-ISSN 2196-3053
Zeitschrift Current Treatment Options in Allergy
Quellenangaben Band: 13, Heft: 1, Seiten: , Artikelnummer: 4 Supplement: ,
Verlag Springer
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)