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Barayeu, U.* ; Ogata, S.* ; Takata, T.* ; Jung, M.* ; Matsunaga, T.* ; Morita, M.* ; Ida, T.* ; Lange, M.* ; Unno, Y.* ; Boushehri, S.* ; Greicius, P.* ; Nishimura, A.* ; Catti, L.* ; Pan, Y.* ; Zhang, T.* ; Shimizu, T.* ; Ushioda, R.* ; Nakabayashi, T.* ; Asamitsu, S.* ; Fusegawa, K.* ; Suzuki, T.* ; Ishida, T.* ; Tanda, N.* ; Watanabe, Y.* ; Tsuchiya, Y.* ; Yamaguchi, R.* ; Noguchi, S.* ; Mishima, E. ; Yano, F.* ; Arisawa, M.* ; Stuehr, D.J.* ; Xia, N.* ; Li, H.* ; Moosmann, B.* ; Gräter, F.* ; Aponte-Santamaría, C.* ; Olzmann, J.A.* ; Conrad, M. ; van der Vliet, A.* ; Dick, T.P.* ; Motohashi, H.* ; Yoshizawa, M.* ; Akaike, T.*

Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis.

Science 393:eaec5473 (2026)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its most stable allotrope, cyclo-octasulfur (S8). We found that S8 accumulates to millimolar concentrations in mitochondrial membranes and in lipid droplets in both mouse and human cells. We further identified lipid droplet-associated nitric oxide synthase as a source of S8 biosynthesis and found that S8 accumulation in lipid droplets limits lipid peroxidation and suppresses ferroptosis. Accordingly, intra-articular injection of solubilized S8 reduces lipid peroxidation in a mouse model of osteoarthritis. Together, these findings reveal an endogenous pool of S8 in mammals that may protect cells from oxidative membrane damage by modulating cellular sensitivity to ferroptosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nitric-oxide Synthase; Particle Mesh Ewald; Elemental Sulfur; Molecular-dynamics; Force-field; Software News; Gui; Expression; Simulations; Algorithm
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 393, Heft: 6818, Seiten: , Artikelnummer: eaec5473 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Metabolism and Cell Death (MCD)
Förderungen DFG
Bakar Spark award
NIH
Klaus Tschira Foundation
European Research Council (ERC)
German Research Council (DFG)
ERC
National Institutes of Health (NIH)
Japan Society for the Promotion of Science (JSPS)
JSPS KAKENHI
Japan Science and Technology Agency (JST), CREST, Japan
FOREST Program, Japan
Japan Agency for Medical Research and Development (AMED), Japan
Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan