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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A physical, genetic and functional sequence assembly of the barley genome.
Nature 491, 711-716 (2012)
Barley (Hordeum vulgare L.) is among the world's earliest domesticated and most important crop plants. It is diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present an integrated and ordered physical, genetic and functional sequence resource that describes the barley gene-space in a structured whole-genome context. We developed a physical map of 4.98 Gb, with more than 3.90 Gb anchored to a high-resolution genetic map. Projecting a deep whole-genome shotgun assembly, complementary DNA and deep RNA sequence data onto this framework supports 79,379 transcript clusters, including 26,159 'high-confidence' genes with homology support from other plant genomes. Abundant alternative splicing, premature termination codons and novel transcriptionally active regions suggest that post-transcriptional processing forms an important regulatory layer. Survey sequences from diverse accessions reveal a landscape of extensive single-nucleotide variation. Our data provide a platform for both genome-assisted research and enabling contemporary crop improvement.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Messenger-rna Decay ; Mildew Resistance Locus ; Hordeum-vulgare L. ; Noncoding Rnas ; Evolution ; Map ; Expression ; Rice ; Arabidopsis ; Reveals
ISSN (print) / ISBN
0028-0836
e-ISSN
1476-4687
Zeitschrift
Nature
Quellenangaben
Band: 491,
Heft: 7426,
Seiten: 711-716
Verlag
Nature Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed