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Chmelevsky, D. ; Guttenberger, R. ; Kummermehr, J.C.* ; Kellerer, A.M.

A nonparametric method for the derivation of αbeta; ratios from the effect of fractionated irradiations.

Int. J. Radiat. Biol. 59, 1253-1268 (1991)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence. The analysis is employed to derive the αbeta; ratios of the linear-quadratic dose dependence, and different methods have been developed for this purpose. A common method uses the so-called Fe plot. A more complex but also more rigorous method has been introduced by Lam et al. (1979). Their method, which is based on numerical optimization procedures, is generalized and somewhat simplified in the present study. Tumour-regrowth data are used to explain the nonparametric procedure which provides αbeta; ratios without the need to postulate analytical expressions for the relationship between cell survival and regrowth delay.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0955-3002
e-ISSN 1362-3095
Zeitschrift International Journal of Radiation Biology
Quellenangaben Band: 59, Heft: 5, Seiten: 1253-1268 Artikelnummer: , Supplement: ,
Verlag Informa Healthcare
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)