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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Oncogenic potential of hepatitis B virus encoded proteins.
Curr. Opin. Virol. 14, 109-115 (2015)
Due to the limited treatment options hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death, and hepatitis B virus (HBV) infection is the major risk factor for development of HCC worldwide. HCC is typically preceded by chronic inflammation, but may also develop in the absence of liver disease on the basis of HBV infection and even when virus replication is controlled by antivirals. In this situation, HBV antigen expression persists and direct oncogenic effects of HBV are integration of the viral DNA into the host genome as well as direct effects of viral proteins. These factors have to be taken into account in order to personalize HCC surveillance in CHB and unravel novel therapeutic approaches.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
ISSN (print) / ISBN
1879-6257
e-ISSN
1879-6265
Zeitschrift
Current Opinion in Virology
Quellenangaben
Band: 14,
Seiten: 109-115
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)