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Butenandt, O.* ; Jocham, A.* ; Schwarz, H.P.* ; Sperlich, M.* ; Tschöp, M.H.

Childhood onset of GH deficiency: Reassessment of GH status and effects of substitution.

Growth Horm. IGF Res. 8 Suppl A, 9-13 (1998)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The final height of 77 patients with growth hormone (GH) insufficiency of childhood onset was analysed. Patients were treated between 1968 and 1996 for 1-15 years. The mean final height in patients with severe GH deficiency was 163.9 cm (males) or 151.1 cm (female patients). In patients with partial GH insufficiency, the mean final heights were 166.2 and 157.7 cm, respectively, and in patients with GH deficiency caused by intracerebral tumours, 175.9 or 160.2 cm, respectively. Late established diagnosis, lack of (pituitary) GH during the time prior to 1980 or low frequency of injections per week were related to the fact that final height was often below the target height range. In four of 51 retested patients with childhood onset GH deficiency, a normal response of the pituitary gland to pharmacological testing was found, whereas all other patients still suffered from GH insufficiency. An increased amount of fat and a decreased amount of lean body mass as well as low bone mineral density (12 out of 15 patients) could be demonstrated at re-evaluation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1096-6374
e-ISSN 1096-6374
Zeitschrift Growth Hormone and IGF Research
Quellenangaben Band: 8 Suppl A, Heft: , Seiten: 9-13 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)