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Peller, M.* ; Reinl, H.M. ; Weigel, A.* ; Meininger, M.* ; Issels, R.D. ; Reiser, M.*

T1 Relaxation Time at 0.2 Tesla for Monitoring Regional Hyperthermia : Feasibility Study in Muscle and Adipose Tissue.

Magn. Reson. Med. 47, 1194-1201 (2002)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The purpose of this study was to characterize T-1, particularly in the hyperthermia temperature range (ca. 37-44degreesC), in order to control regional hyperthermia with MR monitoring using 0.2 Tesla, and to improve T-1 mapping. A single-slice and a new multislice T One by Multiple Read-Out Pulses" (TOMROP) pulse sequence were used for fast ill mapping in a clinical MRI hyperthermia hybrid system. Temporal stability, temperature sensitivity, and reversibility of T-1 were investigated in a polyamidacryl gel phantom and in samples of muscle and adipose tissues from turkey and pig, and verified in patients. In the gel phantom a high linear correlation between T-1 and temperature (R-2 = 0.97) was observed. In muscle and adipose tissue, T-1 and temperature had a linear relationship below a breakpoint of 43degreesC. Above this breakpoint muscle tissue showed irreversible tissue changes; these effects were not visible in adipose tissue. The ex vivo results were confirmed in vivo under clinical conditions. T-1, mapping allows the characterization of hyperthermia-related tissue response in healthy tissue. T-1, in combination with fast mapping, is suitable for controlling regional hyperthermia at 0.2 T within the hybrid system."
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter MRI; MR thermometry; hyperthermia; T 1 mapping; thermal therapy
Sprache englisch
Veröffentlichungsjahr 2002
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0740-3194
e-ISSN 1522-2594
Zeitschrift Magnetic Resonance in Medicine
Quellenangaben Band: 47, Heft: , Seiten: 1194-1201 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed
Institut(e) CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-521100-001
Erfassungsdatum 2002-09-03
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