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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Identifying dose dependences of the two-stage clonal expansion model with simulated cohorts.
J. Radiol. Prot. 22, 57-60 (2002)
The two-stage clonal expansion model of cancer induction is tested on recorded and simulated cohort data of radon-exposed rats. Unfortunately, different versions of the model, for which radiation acts on different biological processes, can provide a good description of the data. This is the case for an initiation-transformation and an initiation-promotion model when they are applied to lung tumour data of radon-exposed rats and all malignant tumours are assumed to be incidental. However, if one were able to use information on fatal tumours as well, the two models could be separated by their deviances.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0952-4746
e-ISSN
1361-6498
Zeitschrift
Journal of Radiological Protection
Quellenangaben
Band: 22,
Seiten: 57-60
Verlag
Institute of Physics Publishing (IOP)
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)