Hinweise zu Qualitätskriterien von Zeitschriften
Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016
CC Licencences
Metriken für Publikationen
Startseite
Login
English
Neuer EVA Antrag
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
HGF Fortschrittsbericht
OA Publikationen
Neue Publikation eintragen
Neue Publikation holen aus...
Fehlende Publikation melden
Ansprechpartner
Hilfe
Bibliometrische Indikatoren
Text
Endnote (RIS)
BibTeX
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?
Clin. Chem. Lab. Med. 47, 398-404 (2009)
Background: Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1b), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC). Alleles TNFA-238A, IL1B-31T and variant IL1RN*2 of repeat polymorphism in the gene encoding the IL-1 receptor antagonist increase production of TNF-alpha and IL-1b, respectively. Alleles CD14-159T, TLR4 c.896G and TLR4 c.1196T modify activation of Kupffer cells by endotoxin. We confirmed the published associations between these common variants and genetic predisposition to ALC by means of a large case-control association study conducted on two Central European populations. Methods: The study population comprised a Czech sample of 198 ALC patients and 370 controls (MONICA project), and a German sample of 173 ALC patients and 331 controls (KORA-Augsburg), and 109 heavy drinkers without liver disease. Results: Single locus analysis revealed no significant difference between patients and controls in all tested loci. Diplotype [IL1RN*2/*2; IL1B-31T+] was associated with increased risk of ALC in the pilot study, but not in the validation samples. Conclusions: Although cytokine mediated immune reactions play a role in the pathogenesis of ALC, hereditary susceptibility caused by variants in the corresponding genes is low in Central European populations.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
1.888
0.700
8
10
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
alcoholic; genetic; interleukin-1 beta; liver cirrhosis; polymorphism; tumor necrosis factor-alpha; necrosis-factor-alpha; promoter polymorphism; japanese patients; deficient mice; receptor gene; risk-factor; in-vitro; disease; injury; association
Sprache
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
2009
ISSN (print) / ISBN
1434-6621
e-ISSN
1437-4331
Zeitschrift
Clinical Chemistry and Laboratory Medicine
Quellenangaben
Band: 47,
Heft: 4,
Seiten: 398-404
Verlag
de Gruyter
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500700-001
G-503900-001
G-504090-001
G-503900-001
G-504090-001
Scopus ID
63849311404
PubMed ID
19278365
Erfassungsdatum
2009-07-09