PuSH - Publikationsserver des Helmholtz Zentrums München: Half-lives of tetra-, penta-, hexa-, hepta-, and octachlorodibenzo-p-dioxins in rats, monkeys and humans-a critical review.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Geyer, H.J. ; Schramm, K.-W. ; Feicht, E.A. ; Behechti, A. ; Steinberg, C.* ; Brüggemann, R.* ; Poiger, H.* ; Henkelmann, B. ; Kettrup, A.

Half-lives of tetra-, penta-, hexa-, hepta-, and octachlorodibenzo-p-dioxins in rats, monkeys and humans-a critical review.

Chemosphere 48, 631-644 (2002)

DOI

Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

The elimination half-lives (t(1/2)) in Sprague-Dawley rats for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2, 3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD), 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) and 1,2,3,4,6,7,8,9-octachlorodibetizo-p-dioxin (OCDD) were estimated in long-term studies by Schlatter, Poiger and others. Furthermore, there are some published half-lives of TCDD in adult humans. The average half-life of TCDD in adult humans is approximately 2840 days, while in Sprague-Dawley rats the average t(1/2) of TCDD is 19 days. The t(1/2) of TCDD in humans is about 150 times that of rats. This factor was used to calculate the t(1/2) values of the other polychlorinated dibenzo-p-dioxins (PCDDs) in humans from the rat data. Furthermore, the terminal t(1/2) Values Of PCDDs in adult humans were calculated from the regression equation: log t(1/2H) = 1.34 log t(1/2R) + 1.25 which was recently established for 50 xenobiotics (t(1/2H) = terminal half-lives in days for humans, t(1/2R) = terminal half-lives in days for rats). The following terminal half-lives in adult humans were obtained: 12.6 years for 1,2,3,7,8-PeCDD, 26-45 years for 1,2,3,4,7,8-HxCDD, 80 102 years for 1,2,3,4,6,7,8-HpCDD and ca. 112-132 years for OCDD. These half-lives of PCDDs are critically compared with measured t(1/2) values of PCDDs and other persistent organic pollutants in rats, monkeys and humans.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

1.181

0.000