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Heissenhuber, A. ; Heinrich, J. ; Fahlbusch, B.* ; Borte, M.* ; Wichmann, H.-E. ; Bolte, G.*

Health impacts of second-hand exposure to cat allergen Del d 1 in infants.

Allergy 58, 154-157 (2003)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Recent cross-sectional studies suggested that highest sensitization prevalences occur with moderate cat allergen exposures. We aimed to assess the impact of moderate levels of second-hand cat allergen exposure on the incidence of specific sensitization and wheezing in the framework of a birth cohort study. Therefore we restricted our analysis to infants without a cat at home since birth. Methods: At infant's age 3 months, cat allergen levels were measured in the mattress dust of 1840 families without cats. At age 2 years, serum IgE specific to Fel d 1 was analyzed. Incidence of wheezing apart from respiratory infection was assessed by questionnaire. Logistic regression models were used to calculate adjusted odds ratios (OR) for the association between second-hand cat allergen exposure and health outcomes. Results: Until age 2 years, 13 of 1301 infants (1%) were sensitized to cat allergen and 56 of 1492 infants (4%) had ever-wheezing without infection. Early exposure to second-hand cat allergen levels ≥ 1 µg/g dust increased substantially the risk for specific sensitization to Fel d 1 (OR 10.9, 95% CI 3.4–35.0) and ever-wheeze without infection (OR 2.0, 95% CI 1.1–3.9) at age 2 years. Conclusions: Second-hand exposure to cat allergen in homes without cats is detrimental in terms of allergy development in infants.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter allergy; asthma; cat allergen; cohort study; IgE sensitization
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 58, Heft: 2, Seiten: 154-157 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)