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Pernot, E.* ; Hall, J.* ; Baatout, S.* ; Benotmane, M.A.* ; Blanchardon, E.* ; Bouffler, S.* ; El Saghire, H.* ; Gomolka, M. ; Guertler, A. ; Harms-Ringdahl, M.* ; Jeggo, P.* ; Kreuzer, M. ; Laurier, D.* ; Lindholm, C.* ; Mkacher, R.* ; Quintens, R.* ; Rothkamm, K.* ; Sabatier, L.* ; Tapio, S. ; de Vathaire, F.* ; Cardis, E.*

Ionizing radiation biomarkers for potential use in epidemiological studies.

Mutat. Res.- Rev. Mutat. Res. 751, 258-286 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ionizing radiation is a known human carcinogen that can induce a variety of biological effects depending on the physical nature, duration, doses and dose-rates of exposure. However, the magnitude of health risks at low doses and dose-rates (below 100mSv and/or 0.1mSvmin(-1)) remains controversial due to a lack of direct human evidence. It is anticipated that significant insights will emerge from the integration of epidemiological and biological research, made possible by molecular epidemiology studies incorporating biomarkers and bioassays. A number of these have been used to investigate exposure, effects and susceptibility to ionizing radiation, albeit often at higher doses and dose rates, with each reflecting time-limited cellular or physiological alterations. This review summarises the multidisciplinary work undertaken in the framework of the European project DoReMi (Low Dose Research towards Multidisciplinary Integration) to identify the most appropriate biomarkers for use in population studies. In addition to logistical and ethical considerations for conducting large-scale epidemiological studies, we discuss the relevance of their use for assessing the effects of low dose ionizing radiation exposure at the cellular and physiological level. We also propose a temporal classification of biomarkers that may be relevant for molecular epidemiology studies which need to take into account the time elapsed since exposure. Finally, the integration of biology with epidemiology requires careful planning and enhanced discussions between the epidemiology, biology and dosimetry communities in order to determine the most important questions to be addressed in light of pragmatic considerations including the appropriate population to be investigated (occupationally, environmentally or medically exposed), and study design. The consideration of the logistics of biological sample collection, processing and storing and the choice of biomarker or bioassay, as well as awareness of potential confounding factors, are also essential.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Low dose ionizing radiation; Biomarkers; DoReMi; MELODI; Molecular epidemiology
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1383-5742
e-ISSN 1388-2139
Zeitschrift Mutation Research / Reviews in Mutation Research
Quellenangaben Band: 751, Heft: 2, Seiten: 258-286 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-500200-001
PubMed ID 22677531
DOI 10.1016/j.mrrev.2012.05.003
WOS ID WOS:000309617500005
Scopus ID 84865634846
Erfassungsdatum 2012-10-19
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