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Raue, A.* ; Kreutz, C.* ; Theis, F.J. ; Timmer, J.

Joining forces of Bayesian and frequentist methodology: A study for inference in the presence of non-identiability.

Philos. Trans. R. Soc. A - Math. Phys. Eng. Sci. 371:20110544 (2013)
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Increasingly complex applications involve large datasets in combination with nonlinear and high dimensional mathematical models. In this context, statistical inference is a challenging issue that calls for pragmatic approaches that take advantage of both Bayesian and frequentist methods. The elegance of Bayesian methodology is founded in the propagation of information content provided by experimental data and prior assumptions to the posterior probability distribution of model predictions. However, for complex applications experimental data and prior assumptions potentially constrain the posterior probability distribution insuciently. In these situations Bayesian Markov chain Monte Carlo sampling can be infeasible. From a frequentist point of view insucient experimental data and prior assumptions can be interpreted as non-identi ability. The pro le likelihood approach o ers to detect and to resolve non-identi ability by experimental design iteratively. Therefore, it allows one to better constrain the posterior probability distribution until Markov chain Monte Carlo sampling can be used securely. Using an application from cell biology we compare both methods and show that a successive application of both methods facilitates a realistic assessment of uncertainty in model predictions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter identi ability, pro le likelihood, Bayesian Markov chain Monte Carlo sampling, posterior propriety, propagation of uncertainty, prediction uncertainty; Profile Likelihood ; Improper Priors ; Models ; Range
Sprache englisch
Veröffentlichungsjahr 2013
Prepublished im Jahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1364-503X
e-ISSN 1471-2962
Zeitschrift Philosophical Transactions of the Royal Society of London, Series A
Quellenangaben Band: 371, Heft: 1984, Seiten: , Artikelnummer: 20110544 Supplement: ,
Verlag Royal Society of London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503700-004
PubMed ID 23277602
DOI 10.1098/rsta.2011.0544
WOS ID WOS:000312959700006
Erfassungsdatum 2012-10-30
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