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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Genetic variation in metabolic phenotypes: Study designs and applications.
Nat. Rev. Genet. 13, 759-769 (2012)
Verlagsversion Volltext
DOI
PMC
Many complex disorders are linked to metabolic phenotypes. Revealing genetic influences on metabolic phenotypes is key to a systems-wide understanding of their interactions with environmental and lifestyle factors in their aetiology, and we can now explore the genetics of large panels of metabolic traits by coupling genome-wide association studies and metabolomics. These genome-wide association studies are beginning to unravel the genetic contribution to human metabolic individuality and to demonstrate its relevance for biomedical and pharmaceutical research. Adopting the most appropriate study designs and analytical tools is paramount to further refining the genotype-phenotype map and eventually identifying the part played by genetic influences on metabolic phenotypes. We discuss such design considerations and applications in this Review.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
38.075
3.565
116
135
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
GENOME-WIDE ASSOCIATION; HDL-CHOLESTEROL CONCENTRATIONS; CHRONIC KIDNEY-DISEASE; COMMON VARIANTS; SUSCEPTIBILITY LOCI; BILIRUBIN LEVELS; ACID INTAKE; METAANALYSIS; INDIVIDUALITY; INTERACTS
Sprache
englisch
Veröffentlichungsjahr
2012
HGF-Berichtsjahr
2012
ISSN (print) / ISBN
1471-0056
e-ISSN
1471-0064
Zeitschrift
Nature Reviews - Genetics
Quellenangaben
Band: 13,
Heft: 11,
Seiten: 759-769
Verlag
Nature Publishing Group
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Genetic Epidemiology (IGE)
Institute of Genetic Epidemiology (IGE)
POF Topic(s)
30505 - New Technologies for Biomedical Discoveries
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er)
Enabling and Novel Technologies
Genetics and Epidemiology
Genetics and Epidemiology
PSP-Element(e)
G-503700-001
G-504100-001
G-504100-001
PubMed ID
23032255
DOI
10.1038/nrg3314
WOS ID
WOS:000310218200006
Scopus ID
84867744660
Erfassungsdatum
2012-10-31