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Endele, M. ; Schroeder, T.

Molecular live cell bioimaging in stem cell research.

Ann. NY Acad. Sci. 1266, 18-27 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Functional heterogeneity within stem and progenitor cells has been shown to influence cell fate decisions. Similarly, intracellular signaling activated by external stimuli is highly heterogeneous and its spatiotemporal activity is linked to future cell behavior. To quantify these heterogeneous states and link them to future cell fates, it is important to observe cell populations continuously with single cell resolution. Live cell imaging in combination with fluorescent biosensors for signaling activity serves as a powerful tool to study cellular and molecular heterogeneity and the long-term biological effects of signaling. Here, we describe these methodologies, their advantages over classical approaches, and we illustrate how they could be applied to improve our understanding of the importance of heterogeneous cellular and molecular responses to external signaling cues.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter biosensors; cytokines; M-CSF; signaling; lineage choice; stem cell; imaging; time lapse; Protein-Kinase-C; Stimulating Factor-I; Hematopoietic Progenitor Cells; Infrared Fluorescent Proteins; Receptor Tyrosine Kinase; M-Csf Receptor; Self-Renewal; Lineage Commitment; Living Cells; Scaffolding Protein
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0077-8923
e-ISSN 1749-6632
Zeitschrift Annals of the New York Academy of Sciences
Quellenangaben Band: 1266, Heft: 1, Seiten: 18-27 Artikelnummer: , Supplement: ,
Verlag New York Academy of Sciences
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Stem Cell Dynamics (SCD)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-501200-001
PubMed ID 22901252
DOI 10.1111/j.1749-6632.2012.06560.x
WOS ID WOS:000312595400004
Scopus ID 84865352787
Erfassungsdatum 2012-11-08
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