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Little, M.P.* ; Azizova, T.V.* ; Bazyka, D.* ; Bouffler, S.D.* ; Cardis, E.* ; Chekin, S.* ; Chumak, V.V.* ; Cucinotta, F.A.* ; de Vathaire, F.* ; Hall, P.* ; Harrison, J.D.* ; Hildebrandt, G.* ; Ivanov, V.* ; Kashcheev, V.V.* ; Klymenko, S.V.* ; Kreuzer, M.* ; Laurent, O.* ; Ozasa, K.* ; Schneider, T.* ; Tapio, S. ; Taylor, A.M.* ; Tzoulaki, I.* ; Vandoolaeghe, W.L.* ; Wakeford, R.* ; Zablotska, L.B.* ; Zhang, W.* ; Lipshultz, S.E.*

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

Environ. Health Perspect. 120, 1503-1511 (2012)
Verlagsversion Volltext DOI PMC
Open Access Gold
Background: Although high doses of ionizing radiation have long been linked to circulatory disease, evidence for an association at lower exposures remains controversial. However, recent analyses suggest excess relative risks at occupational exposure levels.Objectives: We performed a systematic review and meta-analysis to summarize information on circulatory disease risks associated with moderate- and low-level whole-body ionizing radiation exposures.Methods: We conducted PubMed/ISI Thomson searches of peer-reviewed papers published since 1990 using the terms "radiation" AND "heart" AND "disease," OR "radiation" AND "stroke," OR "radiation" AND "circulatory" AND "disease." Radiation exposures had to be whole-body, with a cumulative mean dose of < 0.5 Sv, or at a low dose rate (< 10 mSv/day). We estimated population risks of circulatory disease from low-level radiation exposure using excess relative risk estimates from this meta-analysis and current mortality rates for nine major developed countries.Results: Estimated excess population risks for all circulatory diseases combined ranged from 2.5%/Sv [95% confidence interval (CI): 0.8, 4.2] for France to 8.5%/Sv (95% CI: 4.0, 13.0) for Russia.Conclusions: Our review supports an association between circulatory disease mortality and low and moderate doses of ionizing radiation. Our analysis was limited by heterogeneity among studies (particularly for noncardiac end points), the possibility of uncontrolled confounding in some occupational groups by lifestyle factors, and higher dose groups (> 0.5 Sv) generally driving the observed trends. If confirmed, our findings suggest that overall radiation-related mortality is about twice that currently estimated based on estimates for cancer end points alone (which range from 4.2% to 5.6%/Sv for these populations).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter cancer; circulatory disease; heart disease; radiation; stroke; ATOMIC-BOMB SURVIVORS; CORONARY-HEART-DISEASE; POWER INDUSTRY WORKERS; NUCLEAR-FUELS PLC; LOW-DOSE EXPOSURE; CARDIOVASCULAR-DISEASE; EPIDEMIOLOGIC EVIDENCE; MAYAK PA; CANCER; COHORT
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Zeitschrift Environmental Health Perspectives
Quellenangaben Band: 120, Heft: 11, Seiten: 1503-1511 Artikelnummer: , Supplement: ,
Verlag Research Triangle Park
Verlagsort NC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-500200-001
PubMed ID 22728254
DOI 10.1289/ehp.1204982
WOS ID WOS:000311070000017
Scopus ID 84868520854
Erfassungsdatum 2012-11-09
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