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Scholz, S.W.* ; Houlden, H.* ; Schulte, C.* ; Sharma, M.* ; Li, A.* ; Berg, D.* ; Melchers, A.* ; Paudel, R.* ; Gibbs, J.R.* ; Simon-Sanchez, J.* ; Paisan-Ruiz, C.* ; Bras, J.* ; Ding, J.* ; Chen, H.* ; Traynor, B.J.* ; Arepalli, S.* ; Zonozi, R.R.* ; Revesz, T.* ; Holton, J.* ; Wood, N.* ; Lees, A.* ; Oertel, W.* ; Wüllner, U.* ; Goldwurm, S.* ; Pellecchia, M.T.* ; Illig, T. ; Riess, O.* ; Fernandez, H.H.* ; Rodriguez, R.L.* ; Okun, M.S.* ; Poewe, W.* ; Wenning, G.K.* ; Hardy, J.A.* ; Singleton, A.B.* ; Gasser, T.*

SNCA variants are associated with increased risk for multiple system atrophy.

Ann. Neurol. 65, 610-614 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 × 1012; odds ratio 6.2). © 2009 American Neurological Association.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter alpha-synuclein gene; parkinsons-disease; triplication; diagnosis
ISSN (print) / ISBN 0364-5134
e-ISSN 1531-8249
Zeitschrift Annals of Neurology
Quellenangaben Band: 65, Heft: 5, Seiten: 610-614 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)