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Multhoff, G. ; Pockley, A.G.* ; Streffer, C.* ; Gaipl, U.S.*

Dual role of Heat Shock Proteins (HSPs) in anti-tumor immunity.

Curr. Mol. Med. 12, 1174-1182 (2012)
PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Although surgery and radiotherapy are highly efficient in local tumor control, distal metastases and tumor recurrence often limit therapeutic outcome. It is becoming progressively more evident that curative tumor therapy depends on the presence and maintenance of an intact immune system which has the capacity to elicit cytotoxic effector functions against circulating tumor cells and distant metastases. Heat shock proteins (HSPs, also termed stress proteins) are involved in antigen processing and presentation and can act as "danger signals" for the adaptive and innate immune systems. This article reviews current knowledge relating to the induction and manifestation of stress protein-related immunological responses that are pertinent to the development and maintenance of protective anti-tumor immunity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adaptive immunity; antigen presentation; dendritic cells; immunogenic cell death; innate immunity; macrophages; NK cells; T cells; REGULATORY T-CELLS; TUMOR-ASSOCIATED MACROPHAGES; MHC CLASS-I; IMMUNOLOGICAL SELF-TOLERANCE; RANGE THERMAL-STRESS; NATURAL-KILLER-CELLS; HEAT-SHOCK-PROTEIN-70 HSP70; DOWN-REGULATION; LYMPHOCYTE TRAFFICKING; INFLAMMATORY RESPONSES
ISSN (print) / ISBN 1566-5240
e-ISSN 1875-5666
Zeitschrift Current Molecular Medicine
Quellenangaben Band: 12, Heft: 9, Seiten: 1174-1182 Artikelnummer: , Supplement: ,
Verlag Bentham Science Publishers
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)