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Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling.
Nat. Rev. Genet. 10, 371-380 (2009)
The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions-the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
zinc-finger nucleases; mice lacking vimentin; chromosome substitution strains; copy-number variation; enu mutagenesis; collaborative cross; rna interference; phenome project; complex traits; gene-function
ISSN (print) / ISBN
1471-0056
e-ISSN
1471-0064
Zeitschrift
Nature Reviews - Genetics
Quellenangaben
Band: 10,
Heft: 6,
Seiten: 371-380
Verlag
Nature Publishing Group
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed