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Beckers, J. ; Wurst, W. ; Hrabě de Angelis, M.

Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling.

Nat. Rev. Genet. 10, 371-380 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions-the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter zinc-finger nucleases; mice lacking vimentin; chromosome substitution strains; copy-number variation; enu mutagenesis; collaborative cross; rna interference; phenome project; complex traits; gene-function
Sprache
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 2009
ISSN (print) / ISBN 1471-0056
e-ISSN 1471-0064
Zeitschrift Nature Reviews - Genetics
Quellenangaben Band: 10, Heft: 6, Seiten: 371-380 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
POF Topic(s) 30201 - Metabolic Health
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500600-003
G-500600-004
G-500500-001
DOI 10.1038/nrg2578
Scopus ID 67349229121
PubMed ID 19434078
Erfassungsdatum 2009-07-09
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