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Wilde, S. ; Schendel, D.J.

High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them.

OncoImmunology 1, 1643-1644 (2012)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The adoptive transfer of lymphocytes expressing high-avidity T-cell receptors with antitumor specificity provides a promising therapy for cancer patients. Recently, we compared 12 HLA-A2-restricted, tyrosinase peptide-specific CD8+ cytotoxic T-lymphocyte (CTL) clones and demonstrated that polyfunctional type 1 helper (Th1)-cytokine secretion serves to rapidly select high-quality, high-avidity CTLs.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Sonstiges: Meinungsartikel
Korrespondenzautor
Schlagwörter Adoptive T Cell Therapy ; Human Cytotoxic Cd8(+) T Lymphocytes ; Melanoma ; T-cell Receptor ; Tcr Gene Therapy ; Th1/th2 Polycytokines; Receptor Gene-therapy ; Cancer ; Sensitivity ; Recognition ; Tcr
ISSN (print) / ISBN 2162-4011
e-ISSN 2162-402X
Zeitschrift OncoImmunology
Quellenangaben Band: 1, Heft: 9, Seiten: 1643-1644 Artikelnummer: , Supplement: ,
Verlag Taylor & Francis
Verlagsort Philadelphia
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)