The adoptive transfer of lymphocytes expressing high-avidity T-cell receptors with antitumor specificity provides a promising therapy for cancer patients. Recently, we compared 12 HLA-A2-restricted, tyrosinase peptide-specific CD8+ cytotoxic T-lymphocyte (CTL) clones and demonstrated that polyfunctional type 1 helper (Th1)-cytokine secretion serves to rapidly select high-quality, high-avidity CTLs.
Impact Factor
Scopus SNIP
Web of Science Times Cited
Scopus Cited By
Altmetric
6
7
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
PublikationstypArtikel: Journalartikel
DokumenttypFachkommentar, Meinungsartikel
Typ der Hochschulschrift
Herausgeber
SchlagwörterAdoptive T Cell Therapy ; Human Cytotoxic Cd8(+) T Lymphocytes ; Melanoma ; T-cell Receptor ; Tcr Gene Therapy ; Th1/th2 Polycytokines; Receptor Gene-therapy ; Cancer ; Sensitivity ; Recognition ; Tcr