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Timofeeva, M.N.* ; Hung, R.J.* ; Rafnar, T.* ; Christiani, D.C.* ; Field, J.K.* ; Bickeböller, H.* ; Risch, A.* ; McKay, J.D.* ; Wang, Y.F.* ; Dai, J.C.* ; Gaborieau, V.* ; McLaughlin, J.* ; Brenner, D.* ; Narod, S.A.* ; Caporaso, N.E.* ; Albanes, D.* ; Thun, M.* ; Eisen, T.* ; Wichmann, H.-E. ; Rosenberger, A.* ; Han, Y.H.* ; Chen, W.* ; Zhu, D.K.* ; Spitz, M.* ; Wu, X.F.* ; Pande, M.* ; Zhao, Y.* ; Zaridze, D.* ; Szeszenia-Dabrowska, N.* ; Lissowska, J.* ; Rudnai, P.* ; Fabianova, E.* ; Mates, D.* ; Bencko, V.* ; Foretova, L.* ; Janout, V.* ; Krokan, H.E.* ; Gabrielsen, M.E.* ; Skorpen, F.* ; Vatten, L.* ; Njolstad, I.* ; Chen, C.* ; Goodman, G.* ; Lathrop, M* ; Benhamou, S.* ; Vooder, T.* ; Välk, K.* ; Nelis, M.* ; Metspalu, A.* ; Raji, O.* ; Chen, Y.* ; Gosney, J.* ; Liloglou, T.* ; Muley, T.* ; Dienemann, H.* ; Thorleifsson, G.* ; Shen, H.B.* ; Stefansson, K.* ; Brennan, P.* ; Amos, C.I.* ; Houlston, R.* ; Landi, M.T.*

Influence of common genetic variation on lung cancer risk: Meta-analysis of 14900 cases and 29485 controls.

Hum. Mol. Genet. 21, 4980-4995 (2012)
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Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide Association ; Coronary-artery-disease ; Dna Double-strand ; Susceptibility Loci ; Large-scale ; Japanese Population ; Genotype Imputation ; Nicotine Dependence ; In-vivo ; Variants
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 21, Heft: 22, Seiten: 4980-4995 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e) G-503900-002
G-504200-001
G-504100-001
G-504000-002
PubMed ID 22899653
DOI 10.1093/hmg/dds334
WOS ID WOS:000310369000016
Scopus ID 84868156549
Erfassungsdatum 2012-11-29
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