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Kirchner, H.* ; Heppner, K.M.* ; Tschöp, M.H.

The role of ghrelin in the control of energy balance.

In: Appetite Control. Berlin ; Heidelberg: Springer, 2012. 161-184 (Handb. Exp. Pharmacol. ; 209)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ghrelin is the only potent orexigenic peptide in circulation. It stimulates food intake and leads to positive energy balance, adipogenesis, and body weight gain. However, the physiological significance of ghrelin in the regulation of energy homeostasis is controversial, since loss of ghrelin function in rodents does not necessarily lead to anorexia and weight loss. In this chapter, we discuss the metabolic function of ghrelin and are highlighting recent findings including the discovery and function of ghrelin-acylating enzyme ghrelin O-acyltransferase (GOAT). Based on available published data, we conclude that ghrelin is a principally important endogenous regulator of energy balance, which however may affect both food intake and systemic metabolism via independent mechanisms. Importantly, ghrelin, when acylated by GOAT, might represent a key molecular link between the sensing of consumed calories and the neuroendocrine control of energy homeostasis. Thus, agents antagonizing the action of ghrelin may have therapeutic potential in the therapy of obesity.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber Joost, H.-G.*
Schlagwörter Ghrelin; Ghrelin-O-acyltransferase; Ghrelin activation; Stimulation of food intake
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0171-2004
ISBN 978-3-642-24715-6
Bandtitel Appetite Control
Zeitschrift Handbook of Experimental Pharmacology
Quellenangaben Band: 209, Heft: , Seiten: 161-184 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
PubMed ID 22249814
DOI 10.1007/978-3-642-24716-3_7
Erfassungsdatum 2012-11-29
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