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Gündisch, S. ; Boeckeler, E. ; Behrends, U. ; Amtmann, E.* ; Ehrhardt, H. ; Jeremias, I.

Glucocorticoids augment survival and proliferation of tumor cells.

Anticancer Res. 32, 4251-4261 (2012)
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Open Access Gold
BACKGROUND: Glucocorticoids are widely used for cancer patients, although they can reduce the efficacy of anticancer treatment. MATERIALS AND METHODS: We characterized non-apoptotic actions of glucocorticoids on tumor cell lines, primary tumor cells and an in vivo model, together with molecular signaling studies. RESULTS: Glucocorticoids enhanced cell proliferation in 9/17 cell lines and significantly promoted tumor cell proliferation in a pre-clinical mouse model of lung carcinoma. 65/139 primary acute childhood leukemia samples were glucocorticoid-resistant. Both dexamethasone and prednisolone increased in vitro survival in 21/65 samples from glucocorticoid-resistant primary leukemias, revealing a completely new action of glucocorticoids. Dexamethasone-induced proliferation was mediated by glucocorticoid receptor and activated the proliferation signaling pathways of protein kinase B/AKT and p38 mitogen-activated protein kinase. CONCLUSION: Our data suggest that restriction of the use of glucocorticoids during anticancer treatment might improve the outcome of patients with solid tumors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Tumor cell proliferation; glucocorticoids; glucocorticoid receptor; p38MAPK; AKT; ACUTE LYMPHOBLASTIC-LEUKEMIA; INDUCED APOPTOSIS; BRAIN METASTASES; LUNG-CANCER; DEXAMETHASONE; RECEPTOR; PHARMACOKINETICS; PREDNISOLONE; STIMULATION; PACLITAXEL
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0250-7005
e-ISSN 1791-7530
Zeitschrift Anticancer Research
Quellenangaben Band: 32, Heft: 10, Seiten: 4251-4261 Artikelnummer: , Supplement: ,
Verlag International Institute of Anticancer Research
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501590-001
PubMed ID 23060545
WOS ID WOS:000310111800008
Erfassungsdatum 2012-11-29
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