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Lu, X.* ; Wang, L.* ; Chen, S.* ; He, L.* ; Yang, X.* ; Shi, Y.* ; Cheng, J.* ; Zhang, L.* ; Gu, C.C.* ; Huang, J.* ; Wu, T.* ; Ma, Y.* ; Li, J.* ; Cao, J.* ; Chen, J.* ; Ge, D.* ; Fan, Z.* ; Li, Y.* ; Zhao, L.* ; Li, H.* ; Zhou, X.* ; Chen, L.* ; Liu, D.* ; Duan, X.* ; Hao, Y.* ; Lu, F.* ; Liu, Z.* ; Yao, C.* ; Shen, C.* ; Pu, X.* ; Yu, L.* ; Fang, X.* ; Xu, L.* ; Mu, J.* ; Wu, X.* ; Zheng, R.* ; Wu, N.* ; Zhao, Q.* ; Liu, X.* ; Wang, M.* ; Yu, D.* ; Hu, D.* ; Ji, X.* ; Guo, D.* ; Sun, D.* ; Wang, Q.* ; Yang, Y.* ; Liu, F.* ; Mao, Q.* ; Liang, X.* ; Ji, J.* ; Chen, P.* ; Mo, X.* ; Li, D.* ; Chai, G.* ; Tang, Y.* ; Li, X.* ; Du, Z.* ; Dou, C.* ; Yang, Z.* ; Meng, Q.* ; Wang, D.* ; Wang, R.* ; Yang, J.* ; Schunkert, H.* ; Samani, N.J.* ; Kathiresan, S.* ; Reilly, M.P.* ; Erdmann, J.* ; Peng, X.* ; Chen, R.* ; Qiang, B.* ; Gu, D.* ; CARDIoGRAM Consortium (Wichmann, H.-E. ; Döring, A. ; Illig, T. ; Klopp, N. ; Meisinger, C. ; Peters, A. ; Meitinger, T.)

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

Nat. Genet. 44, 890-894 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; COMMON VARIANTS; EAST ASIANS; METAANALYSIS; POPULATION; SEQUENCE; ONSET
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 44, Heft: 8, Seiten: 890-894 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)