PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Boraska, V.* ; Jeroncic, A.* ; Colonna, V.* ; Southam, L.* ; Nyholt, D.R.* ; William Rayner, N.* ; Perry, J.R.* ; Toniolo, D.* ; Albrecht, E. ; Ang, W.* ; Bandinelli, S.* ; Barbalic, M.* ; Barroso, I.* ; Beckmann, J.S.* ; Biffar, R.* ; Boomsma, D.* ; Campbell, H.* ; Corre, T.* ; Erdmann, J.* ; Esko, T.* ; Fischer, K.* ; Franceschini, N.* ; Frayling, T.M.* ; Girotto, G.* ; Gonzalez, J.R.* ; Harris, T.B.* ; Heath, A.C.* ; Heid, I.M. ; Hoffmann, W.* ; Hofman, A.* ; Horikoshi, M.* ; Hua Zhao, J.* ; Jackson, A.U.* ; Hottenga, J.J.* ; Jula, A.* ; Kähönen, M.* ; Khaw, K.T.* ; Kiemeney, L.A.* ; Klopp, N.* ; Kutalik, Z.* ; Lagou, V.* ; Launer, L.J.* ; Lehtimäki, T.* ; Lemire, M.* ; Lokki, M.L.* ; Loley, C.* ; Luan, J.* ; Mangino, M.* ; Mateo Leach, I.* ; Medland, S.E.* ; Mihailov, E.* ; Montgomery, G.W.* ; Navis, G.* ; Newnham, J.* ; Nieminen, M.S.* ; Palotie, A.* ; Panoutsopoulou, K.* ; Peters, A.* ; Pirastu, N.* ; Polasek, O.* ; Rehnström, K.* ; Ripatti, S.* ; Ritchie, G.R.* ; Rivadeneira, F.* ; Robino, A.* ; Samani, N.J.* ; Shin, S.Y.* ; Sinisalo, J.* ; Smit, J.H.* ; Soranzo, N.* ; Stolk, L.* ; Swinkels, D.W.* ; Tanaka, T.* ; Teumer, A.* ; Tönjes, A.* ; Traglia, M.* ; Tuomilehto, J.* ; Valsesia, A.* ; van Gilst, W.H.* ; van Meurs, J.B.* ; Smith, A.V.* ; Viikari, J.* ; Vink, J.M.* ; Waeber, G.* ; Warrington, N.M.* ; Widen, E.* ; Willemsen, G.* ; Wright, A.F.* ; Zanke, B.W.* ; Zgaga, L.* ; Wellcome Trust Case Consortium (WTCCC) (*) ; Boehnke, M.* ; d'Adamo, A.P.* ; de Geus, E.* ; Demerath, E.W.* ; den Heijer, M.* ; Eriksson, J.G.* ; Ferrucci, L.* ; Gieger, C.* ; Gudnason, V.* ; Hayward, C.* ; Hengstenberg, C.* ; Hudson, T.J.* ; Jarvelin, M.R.* ; Kogevinas, M.* ; Loos, R.J.* ; Martin, N.G.* ; Metspalu, A.* ; Pennell, C.E.* ; Penninx, B.W.* ; Perola, M.* ; Raitakari, O.* ; Salomaa, V.* ; Schreiber, S.* ; Schunkert, H.* ; Spector, T.D.* ; Stumvoll, M.* ; Uitterlinden, A.G.* ; Ulivi, S.* ; van der Harst, P.* ; Vollenweider, P.* ; Völzke, H.* ; Wareham, N.J.* ; Wichmann, H.-E. ; Wilson, J.F.* ; Rudan, I.* ; Xue, Y.* ; Zeggini, E.*

Genome-wide meta-analysis of common variant differences between men and women.

Hum. Mol. Genet. 21, 4805-4815 (2012)
Verlagsversion Volltext DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10(-8)) common SNP differences between men and women in this well-powered meta-analysis. The simulated data provided results entirely consistent with these findings. This large-scale investigation across ∼115 000 individuals shows no detectable contribution from common genetic variants to the observed skew in the sex ratio. The absence of sex-specific differences is useful in guiding genetic association study design, for example when using mixed controls for sex-biased traits.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.636
1.710
22
23
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter HUMAN SEX-RATIO; ASSOCIATION; SIMULATION; DISEASE; BIRTH; TIME
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 21, Heft: 21, Seiten: 4805-4815 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health

30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
G-503900-002
G-504200-001
G-504000-001
G-503900-001
PubMed ID 22843499
DOI 10.1093/hmg/dds304
WOS ID WOS:000310165500018
Scopus ID 84867814813
Erfassungsdatum 2012-12-03
[➜Korrektur melden]