PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Rumenapp, C. ; Smida, J. ; Gonzalez-Vasconcellos, I. ; Baumhoer, D. ; Malfoy, B.* ; Hadj-Hamou, N.S.* ; Sanli-Bonazzi, B. ; Nathrath, M. ; Atkinson, M.J. ; Rosemann, M.

Secondary radiation-induced bone tumours demonstrate a high degree of genomic instability predictive of a poor prognosis.

Curr. Genomics 13, 433-437 (2012)
Verlagsversion Volltext DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Secondary bone tumours arising in the field of a preceding radiotherapy are a serious late effect, in particular considering the increasing survival times in patients treated for paediatric malignancies. In general, therapy associated tumours are known to show a more aggressive behaviour and a limited response to chemotherapy compared with their primary counterparts. It is not clear however whether this less favourable outcome is caused by inherent genetic factors of the tumour cells or by a general systemic condition of the patient. To elucidate this we analysed a series of bone sarcomas with a history of prior irradiation for the presence of genomic alterations and compared them with the alterations identified earlier in primary osteosarcomas. We analysed seven radiation induced bone sarcomas for genome-wide losses of heterozygosity (LOH) using Affymetrix 10K2 high-density single nucleotide polymorphism (SNP) arrays. Additionally, copy number changes were analysed at two distinct loci on 10q that were recently found to be of major prognostic significance in primary osteosarcomas. All the investigated tumours showed a LOH at 10q21.1 with 86% of cases (6/7) revealing a total genome-wide LOH score above 2400 and more than 24% of the genome being affected. Our results indicate similar genetic alterations in radiation induced sarcomas of bone and primary osteosarcomas with a poor prognosis. We speculate that the high degree of genomic instability found in these tumours causes the poor prognosis irrespective of the initiating event.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
2.408
0.733
3
5
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genomic Instability ; Loss-of-heterozygosity ; Osteosarcom ; Predictive Assay ; Radiation-induced ; Snp-array ; Therapy-related ; Therapy Response; Radium Dial Workers ; Postirradiation Sarcomas ; Dose-dependency ; Osteosarcoma ; Children ; Cancer ; Retinoblastoma ; Radiotherapy
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1389-2029
e-ISSN 1875-5488
Zeitschrift Current Genomics
Quellenangaben Band: 13, Heft: 6, Seiten: 433-437 Artikelnummer: , Supplement: ,
Verlag Bentham Science Publishers
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
Institute of Pathology (PATH)
CCG Osteosarcoma (PATH-KOS)
POF Topic(s) 30202 - Environmental Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
Enabling and Novel Technologies
PSP-Element(e) G-500200-001
G-500300-001
G-520800-001
PubMed ID 23450216
WOS ID 000308005700004
DOI 10.2174/138920212802510420
Erfassungsdatum 2012-09-30
[➜Korrektur melden]