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Rieger, M.* ; Schroeder, T.

Hematopoiesis.

Cold Spring Harbor Perspect. Biol. 4:a008250 (2012)
Verlagsversion Volltext DOI PMC
Free by publisher
Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in this system. At the same time, many long-standing disputes in hematopoiesis research illustrate our still limited understanding. Here we discuss the embryonic development and lifelong maintenance of the hematopoietic system, its cellular components, and some of the hypotheses about the molecular mechanisms involved in controlling hematopoietic cell fates.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter STEM-CELL NICHE; TRANSCRIPTION FACTOR PAX5; HUMAN CORD BLOOD; COLONY-STIMULATING FACTOR; REGULATES SELF-RENEWAL; LINEAGE FATE DECISION; MOUSE BONE-MARROW; B-CELL; IN-VIVO; PROGENITOR CELLS
e-ISSN 1943-0264
Zeitschrift Cold Spring Harbor Perspectives in Biology
Quellenangaben Band: 4, Heft: 12, Seiten: , Artikelnummer: a008250 Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Stem Cell Dynamics (SCD)