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Rieger, M.* ; Schroeder, T.

Hematopoiesis.

Cold Spring Harbor Perspect. Biol. 4:a008250 (2012)
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Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in this system. At the same time, many long-standing disputes in hematopoiesis research illustrate our still limited understanding. Here we discuss the embryonic development and lifelong maintenance of the hematopoietic system, its cellular components, and some of the hypotheses about the molecular mechanisms involved in controlling hematopoietic cell fates.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter STEM-CELL NICHE; TRANSCRIPTION FACTOR PAX5; HUMAN CORD BLOOD; COLONY-STIMULATING FACTOR; REGULATES SELF-RENEWAL; LINEAGE FATE DECISION; MOUSE BONE-MARROW; B-CELL; IN-VIVO; PROGENITOR CELLS
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
e-ISSN 1943-0264
Zeitschrift Cold Spring Harbor Perspectives in Biology
Quellenangaben Band: 4, Heft: 12, Seiten: , Artikelnummer: a008250 Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Stem Cell Dynamics (SCD)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-501200-001
PubMed ID 23209149
DOI 10.1101/cshperspect.a008250
WOS ID WOS:000312363400004
Scopus ID 84870737577
Erfassungsdatum 2012-12-31
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