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Yasuno, K.* ; Bilguvar, K.* ; Bijlenga, P.* ; Low, S.K.* ; Krischek, B.* ; Auburger, G.* ; Simon, M.* ; Krex, D.* ; Arlier, Z.* ; Nayak, N.* ; Ruigrok, Y.M.* ; Niemelä, M.* ; Tajima, A.* ; Fraunberg, M.V.Z.* ; Doczi, T.* ; Wirjatijasa, F.* ; Hata, A.* ; Blasco, J.* ; Oszvald, A.* ; Kasuya, H.* ; Zilani, G.* ; Schoch, B.* ; Singh, P.* ; Stüer, C.* ; Risselada, R.* ; Beck, J.* ; Sola, T.* ; Ricciardi, F.* ; Aromaa, A.* ; Illig, T. ; Schreiber, S.* ; van Duijn, C.M.* ; van den Berg, L.H.* ; Perret, C.* ; Proust, C.* ; Roder, C.* ; Ozturk, A.K.* ; Gaal, E.* ; Berg, D.* ; Geisen, C.* ; Friedrich, C.M.* ; Summers, P.* ; Frangi, A.F.* ; State, M.W.* ; Wichmann, H.-E. ; Breteler, M.M.B.* ; Wijmenga, C.* ; Mane, S.* ; Peltonen, L.* ; Elio, V.* ; Sturkenboom, M.C.J.M.* ; Lawford, P.* ; Byrne, J.* ; Macho, J.* ; Sandalcioglu, E.I.* ; Meyer, B.* ; Raabe, A.* ; Steinmetz, H.* ; Rufenacht, D.* ; Jääskeläinen, J.E.* ; Hernesniemi, J.* ; Rinkel, G.J.E.* ; Zembutsu, H.* ; Inoue, I.* ; Palotie, A.* ; Cambien, F.* ; Nakamura, Y.* ; Lifton, R.P.* ; Günel, M.*

Genome-wide association study of intracranial aneurysm identifies three new risk loci.

Nat. Genet. 42, 420-425 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000 genotyped and imputed SNPs across discovery cohorts. We identified three new loci showing strong evidence for association with intracranial aneurysms in the combined dataset, including intervals near RBBP8 on 18q11.2 (odds ratio (OR) = 1.22, P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20, P = 2.5 x 10(-9)) and a gene-rich region on 10q24.32 (OR = 1.29, P = 1.2 x 10(-9)). We also confirmed prior associations near SOX17 (8q11.23-q12.1; OR = 1.28, P = 1.3 x 10(-12)) and CDKN2A-CDKN2B (9p21.3; OR = 1.31, P = 1.5 x 10(-22)). It is noteworthy that several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Population-structure; Imputation; Epidemiology; Probability; Prevalence; Designs; False; Bias
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 42, Heft: 5, Seiten: 420-425 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)