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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
MALDI imaging mass spectrometry for direct tissue analysis.
Methods Mol. Biol. 931, 537-546 (2013)
MALDI (Matrix-Assisted Laser Desorption/Ionization) Imaging mass spectrometry is a powerful new method for analyzing the spatial distribution of molecules in tissues. Several different classes of cellular constituents such as proteins, peptides, lipids, and small molecules can be analyzed in situ while maintaining the morphological integrity of the tissue. This allows a correlation of the morphology with the previously acquired molecular patterns. By this, specific molecules can be clearly assigned to their cellular origin. Here, we will present a protocol for the analysis of proteins in tissues which are either native or alcohol-fixed and paraffin-embedded.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Herausgeber
Taatjes, D.J.* ; Roth, J.*
Schlagwörter
MALDI Imaging; Imaging mass spectrometry; In situ proteomics; Tissue proteomics; Morphology-based tissue analysis
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Konferenztitel
Cell Imaging Techniques : Methods and Protocols
Zeitschrift
Methods in Molecular Biology
Quellenangaben
Band: 931,
Seiten: 537-546
Reihe
Methods in Molecular Biology
Verlag
Springer
Verlagsort
Berlin [u.a.]
Begutachtungsstatus
Peer reviewed