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Lichtenegger, F.S.* ; Schnorfeil, F.M. ; Hiddemann, W. ; Subklewe, M.

Current strategies in immunotherapy for acute myeloid leukemia.

Immunotherapy 5, 63-78 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The prognosis of acute myeloid leukemia, particularly when associated with adverse chromosomal or molecular aberrations, is poor due to a high relapse rate after induction chemotherapy. Postremission therapy for elimination of minimal residual disease remains a major challenge. Allogeneic hematopoietic stem cell transplantation has proven to provide a potent antileukemic effect. Novel strategies are needed for patients ineligible for this treatment. Here current immunotherapeutic concepts in acute myeloid leukemia in a nonallogeneic hematopoietic stem cell transplantation setting are reviewed. Data gathered with different monoclonal antibodies are discussed. Adoptive transfer of NK and T cells is reviewed, including evolving data on T-cell engineering. Results of systemic cytokine administration and of therapeutic vaccinations with peptides, modified leukemic cells and dendritic cells are presented. One particular focus of this review is the integration of currently running clinical trials. Recent immunotherapeutic studies have been encouraging and further interesting results are to be expected.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter acute myeloid leukemia; adoptive cellular therapy; chimeric antigen receptor; dendritic cell vaccination; gemtuzumab ozogamicin; immunotherapy; monoclonal antibody; peptide vaccination; TCR-transgenic; T cell; WT1 PEPTIDE VACCINATION; T-CELL RESPONSES; ACUTE MYELOGENOUS LEUKEMIA; TUMOR PROTEIN-1 WT1; CHIMERIC-ANTIGEN-RECEPTOR; DENDRITIC CELLS; STEM-CELLS; GEMTUZUMAB OZOGAMICIN; COMPLETE REMISSION; ELDERLY-PATIENTS
ISSN (print) / ISBN 1750-743X
e-ISSN 1750-7448
Zeitschrift Immunotherapy
Quellenangaben Band: 5, Heft: 1, Seiten: 63-78 Artikelnummer: , Supplement: ,
Verlag Future Medicine
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Hematopoetic Cell Transplants (IMI-KHZ)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)