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Böhme, M.* ; Grallert, H. ; Klapper, M.* ; Gieger, C. ; Fischer, A.* ; Heid, I.M. ; Wichmann, H.-E. ; Döring, F.* ; Illig, T.

Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study.

Mol. Nutr. Food Res. 53, 681-685 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Studies in relatively small cohorts provide preliminary evidence that functional fatty acid binding protein 2 (FABP2) promoter haplotypes are associated with type 2 diabetes and BMI. Here, we studied the influence of the haplotypes on BMI by using 8072 male and female participants of the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) cohort. By linear regression analysis, we found in males a reduction of -0.39 BMI units (95% CI: -0.73, -0.05, p = 0.024) in homozygous FABP2 promoter haplotype B carriers. Carriers of haplotype B showed a significant decrease in BMI of -0.19 BMI units (95% CI: -0.35, -0.02, p = 0.027). In accordance, a significant reduction in BMI of the minor haplotype carriers in the BMI point categories of 25-30 (BMI units: -0.10, 95% CI: -0.18, -0.01, p = 0.03) and <30 (BMI units: -0.37, 95% CI: -0.67, -0.07, p = 0.02) were found. In summary, the minor FABP2 promoter haplotype B contributes to a reduced BMI in men. This provides evidence that functional FABP2 contributes to multifactorialy regulated body weight.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter BMI; FABP2 gene; KORA; Promoter polymorphism; acid-binding protein-2; proliferator-activated receptorS.; ala54thr polymorphism; insulin-resistance; metabolic syndrome; a54t polymorphism; gene-expression; fat-absorption; obese subjectS.; dietary-fat
ISSN (print) / ISBN 1613-4125
e-ISSN 1613-4133
Zeitschrift Molecular Nutrition and Food Research
Quellenangaben Band: 53, Heft: 6, Seiten: 681-685 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)