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Hyde, D.* ; de Kleine, R.* ; MacLaurin, S.A.* ; Miller, E.* ; Brooks, D.H.* ; Krucker, T.* ; Ntziachristos, V.

Hybrid FMT-CT imaging of amyloid-β plaques in a murine Alzheimer's disease model.

Neuroimage 44, 1304-1311 (2009)

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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

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The need to study molecular and functional parameters of Alzheimer's disease progression in animal models has led to the development of disease-specific fluorescent markers. However, curved optical interfaces and a highly heterogeneous internal structure make quantitative fluorescence imaging of the murine brain a particularly challenging tomographic problem. We investigated the integration of X-ray computed tomography (CT) information into a state-of-the-art fluorescence molecular tomography (FMT) scheme and establish that the dual-modality approach is essential for high fidelity reconstructions of distributed fluorescence within the murine brain, as compared to conventional fluorescence tomography. We employ this method in vivo using a fluorescent oxazine dye to quantify amyloid-beta plaque burden in transgenic APP23 mice modeling Alzheimer's disease. Multi-modal imaging allows for accurate signal localization and correlation of in vivo findings to ex vivo studies. The results point to FMT-CT as an essential tool for in vivo study of neurodegenerative disease in animal models and potentially humans.

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