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Picciotto, S.* ; Forastiere, F.* ; Pistelli, R.* ; Koenig, W.* ; Lanki, T.* ; Ljungman, P.* ; Pitsavos, C.* ; Rückerl, R. ; Sunyer, J.* ; Peters, A.

Determinants of plasma interleukin-6 levels among survivors of myocardial infarction.

Eur. J. Cardiovasc. Prev. Rehabil. 15, 631-638 (2008)
DOI PMC
Background We identify determinants of plasma interleukin-6 (IL-6) levels in a multicenter panel study of myocardial infarction (MI) survivors, using repeated measurements to evaluate both baseline and time-varying factors. Design and methods Survivors of MI (N=1003) recruited in six European cities had repeated measurements (median: 6/patient) of IL-6. At baseline, participants' behaviour and medical histories were determined by interview, and blood pressure, anthropometry, cholesterol and N-terminal B-type natriuretic peptide (NT-proBNP) were measured. Short-term exposures and medication intake were recorded at each visit. Generalized additive mixed models were used to analyze associations of IL-6 with baseline and time-varying risk factors, taking into account repeated measurements. Results Age, hour of blood withdrawal, body mass index, pack-years of smoking, NT-proBNP, systolic blood pressure, high-density lipoprotein cholesterol, persistent cough/phlegm and statin use were significantly and independently associated with IL-6 after adjustment for city, recurrent MI, baseline alcohol intake, current active smoking, tea consumption and extreme anger or stress. Conclusion Among MI survivors, IL-6 levels are associated with many traditional cardiovascular risk factors. Patients with elevated NT-proBNP, respiratory symptoms or obesity had higher IL-6 concentrations and may potentially be at greater risk for coronary artery disease progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter cardiovascular risk factors; cytokines; inflammation; interleukin-6; myocardial infarction; cardiovascular risk-factors; coronary-artery-disease; c-reactive protein; inflammatory markers; heart-disease; metabolic syndrome; adipose-tissue; men; il-6; cytokines
ISSN (print) / ISBN 1350-6277
e-ISSN 1473-5652
Zeitschrift European Journal of Cardiovascular Prevention & Rehabilitation
Quellenangaben Band: 15, Heft: 6, Seiten: 631-638 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)