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Cameron, L.* ; Depner, M.* ; Kormann, M.* ; Klopp, N. ; Illig, T. ; von Mutius, E.* ; Kabesch, M.*

Genetic variation in CRTh2 influences development of allergic phenotypes.

Allergy 64, 1478-1485 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Allergic disorders are characterized by an increase in the Th2 cytokines IL-4, IL-5 and IL-13, produced primarily by Th2 cells. These cells are marked by the expression of CRTh2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), a receptor for prostaglandin D-2. As genetic variation plays a significant role in the predisposition for allergic disorders, we investigated the influence of single nucleotide polymorphisms (SNPs) in CRTh2. Methods: In a large study population of German children (n = 4264) from the International Study of Asthma and Allergy in Children (ISAAC II), six polymorphisms in CRTh2 were genotyped. Statistical analyses were performed using single SNP and haplotype analyses. Results: Uncorrected associations among -6373G > A, +1431G > C and +1538A > G were observed with a number of allergic phenotypes (P < 0.05). After correction, association between +1431C and specific IgE to food allergens remained significant (P = 0.04). Associations of haplotype (H)3 (containing +1538G) with reduced risk for asthma and H2 (containing +1431C) with increased risk for specific IgE to food allergens also remained significant after correction for multiple testing (P = 0.004). Conclusions: Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter asthma; environment; food allergy; single nucleotide polymorphism; IgE; TH2 cells CRTH2; prostaglandin D-2; hay-fever; atopic-dermatitis; receptor CRTH2; asthma; association; children; polymorphisms; population
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 64, Heft: 10, Seiten: 1478-1485 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort MALDEN
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)