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Rosenthal, A. ; Razansky, D. ; Ntziachristos, V.

Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography.

IEEE Trans. Med. Imaging 29, 1275-1285 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We present a fast model-based inversion algorithm for quantitative two- and three-dimensional optoacoustic tomography. The algorithm is based on an accurate and efficient forward model, which eliminates the need for regularization in the inversion process while providing modeling flexibility essential for quantitative image formation. The resulting image-reconstruction method eliminates stability problems encountered in previously published model-based techniques and, thus, enables performing image reconstruction in real time. Our model-based framework offers a generalization of the forward solution to more comprehensive optoacoustic propagation models, such as including detector frequency response, without changing the inversion procedure. The reconstruction speed and other algorithmic performances are demonstrated using numerical simulation studies and experimentally on tissue-mimicking optically heterogeneous phantoms and small animals. In the experimental examples, the model-based reconstructions manifested correctly the effect of light attenuation through the objects and did not suffer from the artifacts which usually afflict the commonly used filtered backprojection algorithms, such as negative absorption values.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Imaging; Inverse problems; Optoacoustics; Photoacoustics; Tomography
ISSN (print) / ISBN 0278-0062
e-ISSN 1558-254X
Zeitschrift IEEE Transactions on Medical Imaging
Quellenangaben Band: 29, Heft: 6, Seiten: 1275-1285 Artikelnummer: , Supplement: ,
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Verlagsort New York, NY [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)