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Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons.
Opt. Lett. 35, 369-371 (2010)
The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2-3, yielding a significant improvement in the tomographic image reconstruction quality.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Turbid media; Molecular tomography
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Zeitschrift
Optics Letters
Quellenangaben
Band: 35,
Heft: 3,
Seiten: 369-371
Verlag
Optical Society of America (OSA)
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed