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Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
Nat. Genet. 42, 24-26 (2010)
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Chromosome Mapping; Cleft Lip/complications; Cleft Lip/genetics; Cleft Palate/complications; Cleft Palate/genetics; Genetic Predisposition to Disease/genetics; Genome-Wide Association Study/methods; Humans; Polymorphism; Single Nucleotide; KORA
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Zeitschrift
Nature Genetics
Quellenangaben
Band: 42,
Heft: 1,
Seiten: 24-26
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed