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Heyder, J. ; Gebhart, J. ; Scheuch, G.

Influence of Human Lung Morphology on Particle Deposition.

J. Aerosol Med. Pulm. Drug Deliv. 1, 81-88 (1988)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Thoracic airway calibers were estimated in 15 healthy subjects from gravitational losses during respiratory pauses of particles inhaled as aerosol boluses to different volumetric depths in the respiratory tract. Intersubject variability of thoracic airway dimensions and particle deposition for controlled and spontaneous mouth-breathing were correlated by Spearman's rank correlation analysis. The correlations between deposition of particles in the diameter range 1 - 5 μm and aerosol derived lung morphology suggest that the intersubject variability of particle deposition is primarily due to morphological differences between individuals. They also confirm the current understanding of behavior in the human respiratory tract of particles larger than 1 μm in diameter: with increasing particle size, the site of deposition is shifted proximally in the lungs.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1988
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0894-2684
e-ISSN 1557-9026
Zeitschrift Journal of Aerosol Medicine and Pulmonary Drug Delivery
Quellenangaben Band: 1, Heft: 2, Seiten: 81-88 Artikelnummer: , Supplement: ,
Verlag Mary Ann Liebert
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)
DOI 10.1089/jam.1988.1.81
Erfassungsdatum 1988-12-31
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