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Jarvis, D.* ; Zock, J.P.* ; Heinrich, J. ; Svanes, C.* ; Verlato, G.* ; Olivieri, M.* ; Villani, S.* ; Ponzio, M.* ; Leynaert, B.* ; Sunyer, J.* ; Dahlman-Höglund, A.* ; Chinn, S.* ; Luczynska, C.* ; Norbäck, D.* ; Burney, P.*

Cat and dust mite allergen levels, specific IgG and IgG4, and respiratory symptoms in adults.

J. Allergy Clin. Immunol. 119, 697-704 (2007)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Exposure to allergen may induce a modified T(H)2 response characterized by high IgG(4) levels, absence of IgE sensitization, and a decreased risk of allergic respiratory symptoms. OBJECTIVE: To assess the association of IgG(4) level with allergic respiratory symptoms in a community-based sample of adults. METHODS: Information on exposure to cats, respiratory symptoms, and mattress allergen levels was obtained from 2780 adults. Levels of cat and house dust mite (HDM) specific IgE, IgG, and IgG(4) were measured. The association of exposure to allergen with IgG(4) and of IgG(4) with symptoms was assessed. RESULTS: Geometric mean (GM) cat specific IgG and IgG(4) was higher in subjects who had a cat that was allowed in the bedroom than in subjects without a cat (adjusted ratio of GM IgG(4), 1.41; 95% CI, 1.25-1.57). Levels of HDM specific IgG and IgG(4) were similar in subjects with undetectable and high (>20.22 microg/g) mattress Der 1 levels (adjusted ratio of GM IgG(4), 1.02; 95% CI, 0.89-1.17). There was no evidence that high cat or HDM specific IgG(4) levels were associated with less IgE sensitization or with fewer symptoms. CONCLUSION: In this community-based sample of adults, high IgG(4) levels to cat or HDM were not associated with a lower risk of allergic respiratory symptoms. CLINICAL IMPLICATIONS: In adults, high cat allergen exposure does not protect against respiratory symptoms.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter ECRHS; IgG; cat; house dust mite
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Zeitschrift The journal of allergy and clinical immunology
Quellenangaben Band: 119, Heft: 3, Seiten: 697-704 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)