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Ucci, G. ; Riccardi, A. ; Dörmer, P. ; Danova, M. ; Luoni, R.

Early Plasma Cell Recruitment in Multiple Myeloma Following Chemotherapy.

Cell Prolif. 21, 405-409 (1988)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Therapy-induced modifications of bone marrow plasma cell kinetics were studied in three patients with myelomatosis. The investigation was performed prior to and 15 d after termination of a course of aggressive chemotherapy. An increase in the labelling index (40-212% of pretreatment values) with a corresponding reduction of Ts (5-34%) was observed in all cases. As a consequence of this combined variation, the fractional turnover rate (which represents the percentage of cells produced per unit time) was the parameter with the highest increment (54-276%). These results indicate that plasma cell recruitment occurs soon after chemotherapy and is characterized by a shorter S phase and a higher number of DNA-synthesizing cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0008-8730
e-ISSN 1365-2184
Zeitschrift Cell Proliferation
Quellenangaben Band: 21, Heft: 6, Seiten: 405-409 Artikelnummer: , Supplement: ,
Verlag Blackwell
Verlagsort Oxford [u.a.] ; Berlin ; Vienna
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)