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Stahlhofen, W. ; Rudolf, G. ; James, A.C.

Intercomparison of Experimental Regional Aerosol Deposition Data.

J. Aerosol Med. Pulm. Drug Deliv. 2, 285-308 (1989)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A critical review is presented of the available experimental data on regional aerosol deposition in man. The data agree well for nasal and extrathoracic deposition. For the fast and slow cleared components of thoracic deposition, however, agreement is less satisfactory. The different experimental techniques are critically evaluated, and possible reasons for the observed discrepancies are discussed. Additionally, a semi-empirical model is presented which takes this evaluation into account, and which enables regional deposition to be calculated as function of particle size and respiratory parameters without lengthy computer models. The proposed equations explain and eliminate some of the intra- and inter-individual scatter of the data, and some of the discrepancies between the data from different laboratories. Where these discrepancies could not be eliminated, an additional 'conservative' model for dose estimations is offered which takes account of the uncertainty inherent to the data. A summary of the model equations is given in the appendix.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0894-2684
e-ISSN 1557-9026
Zeitschrift Journal of Aerosol Medicine and Pulmonary Drug Delivery
Quellenangaben Band: 2, Heft: 3, Seiten: 285-308 Artikelnummer: , Supplement: ,
Verlag Mary Ann Liebert
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Departments & Institutes