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Evidence for Receptor-Mediated Bivalent-Cation Entry in A10 Vascular Smooth-Muscle Cells.
Biochem. J. 267, 277-280 (1990)
n fura-2-loaded A10 vascular smooth-muscle cells, 1 nM-vasopressin and 200 nM-endothelin evoked a rapid transient rise in intracellular free Ca2+ concentration [(Ca2+]i), which was then followed by a maintained elevation of [Ca2+]i. The maintained elevation of [Ca2+]i was only partially inhibited by 5 microM-nifedipine, but completely abolished in the presence of 1 mM-EGTA. When extracellular Ca2+ was replaced with 1 mM-Mn2+ (Mn2+ quenches fura-2 fluorescence), both endothelin and vasopressin evoked an Mn2+ quench of the fluorescence from the intracellularly trapped fura-2, even in the presence of 5 microM-nifedipine. These data suggest that both vasopressin and endothelin promote a bivalent-cation influx and provide further evidence for receptor-mediated Ca2+ entry in vascular smooth muscle.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0264-6021
e-ISSN
1470-8728
Zeitschrift
Biochemical Journal / Reviews
Quellenangaben
Band: 267,
Heft: 1,
Seiten: 277-280
Verlag
Portland Press
Begutachtungsstatus
Peer reviewed