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Holler, E. ; Kolb, H.-J. ; Möller, A. ; Kempeni, J. ; Liesenfeld, S. ; Pechumer, H. ; Lehmacher, W. ; Ruckdeschel, G. ; Gleixner, B. ; Riedner, C. ; Ledderose, G. ; Brehm, G. ; Mittermüller, J. ; Wilmanns, W.

Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation.

Blood 75, 1011-1016 (1990)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Acute graft-versus-host disease, interstitial pneumonitis, endothelial leakage syndrome, and veno-occlusive disease are major complications of bone marrow transplantation. Though several new regimens for prophylaxis and treatment of these syndromes have been introduced, the overall incidence has been only slightly reduced over the last few years. We retrospectively analyzed tumor necrosis factor alpha (TNF alpha) serum levels between day -8 and day 100 after bone marrow transplantation in 56 patients transplanted in our unit for a variety of hematological diseases. In 34 patients with uneventful courses, mean TNF alpha levels rose to a maximum of 76 +/- 29 pg/mL. In contrast, 22 patients with major transplant related complications showed mean increases of TNF alpha of 492 +/- 235 pg/mL (P less than .0001). Increases of TNF alpha occurred before interstitial pneumonitis and severe acute graft-versus-host disease with a latency of 25 to 54 days. Early complications such as endothelial leakage syndrome and veno-occlusive disease were closely associated with increases of TNF alpha serum levels. Our study suggests two pathways of TNF alpha release: activation of host macrophages and stimulation of donor cells in the course of acute graft-versus-host disease. Cytokine monitoring should be helpful for prediction and earlier treatment of major transplant related complications.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 75, Heft: 4, Seiten: 1011-1016 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Department for Medical Information Systems (MEDIS)