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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Intracellular Particle Dissolution in Macrophages Isolated from the Lung of the Fischer(F-344) Rat.
Exp. Lung Res. 20, 143-156 (1994)
Alveolar macrophages were removed from male F-344 rats by bronchoalveolar lavage and maintained in vitro for 14 days. Over this period the macrophages remained viable as judged by propidium iodide exclusion, lysosomal uptake of acridine orange, and phagocytosis of 1.75-microns latex beads. After 7 and 14 days of culture the cells contained lipid droplets. The macrophages were shown to ingest and dissolve monodisperse 57Co3O4 particles, which were relatively insoluble in extracellular medium. The fraction of 57Co3O4 dissolved intracellularly was determined at intervals during the culture period. The mean dissolution rate (+/- SEM) was 0.36 +/- 0.02% per day for the F-344 rat. This was lower than 1.4 +/- 0.05% per day estimated by Kreyling in macrophages from the beagle dog. The significance of this difference is discussed.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0190-2148
e-ISSN
1521-0499
Zeitschrift
Experimental Lung Research
Quellenangaben
Band: 20,
Heft: 2,
Seiten: 143-156
Verlag
Informa Healthcare
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)