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Science 325, 217-218 (2009)
The constant regeneration of the blood system during hematopoiesis requires tightly controlled lineage decisions of hematopoietic progenitor cells (HPCs). Because of technical limitations, differentiation of individual HPCs could not previously be analyzed continuously. It was therefore disputed whether cell-extrinsic cytokines can instruct HPC lineage choice or only allow survival of cells that are already lineage-restricted. Here, we used bioimaging approaches that allow the continuous long-term observation of individual differentiating mouse HPCs. We demonstrate that the physiological cytokines, macrophage colony-stimulating factor and granulocyte colony-stimulating factor, can instruct hematopoietic lineage choice.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
28.103
6.620
200
303
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
colony-stimulating factor; factor-receptor; in-vivo; cells; differentiation; progenitors; commitment; macrophage; granulocyte; expression
Sprache
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
2009
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Zeitschrift
Science
Quellenangaben
Band: 325,
Heft: 5937,
Seiten: 217-218
Verlag
American Association for the Advancement of Science (AAAS)
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
PSP-Element(e)
G-550900-001
PubMed ID
19590005
Scopus ID
67650418221
Erfassungsdatum
2009-09-03